UGT1A4 ELISA Kit for Human(Homo sapiens) | EIAab.comUGT1A4 ELISA Kit for Human(Homo sapiens) | EIAab.com

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UGT1A4 (Gene name),

UDP-glucuronosyltransferase 1-4 (Protein name ), UD14_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

UGT1A4(GNT1;UGT1);

Protein name:

UDP-glucuronosyltransferase 1-4(UDPGT 1-4;UGT1*4;UGT1-04;UGT1.4);

Alternative:

UDP-glucuronosyltransferase 1-D(UGT-1D;UGT1D);Bilirubin-specific UDPGT isozyme 2(hUG-BR2);UDP-glucuronosyltransferase 1A4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate.

Subcellular Location:

Microsome Endoplasmic reticulum membrane Single-pass membrane protein

Protein Attributes:

Sequence length:

534

Sequence:

50:

MARGLQVPLP | RLATGLLLLL | SVQPWAESGK | VLVVPTDGSP | WLSMREALRE |

100:

LHARGHQAVV | LTPEVNMHIK | EEKFFTLTAY | AVPWTQKEFD | RVTLGYTQGF |

150:

FETEHLLKRY | SRSMAIMNNV | SLALHRCCVE | LLHNEALIRH | LNATSFDVVL |

200:

TDPVNLCGAV | LAKYLSIPAV | FFWRYIPCDL | DFKGTQCPNP | SSYIPKLLTT |

250:

NSDHMTFLQR | VKNMLYPLAL | SYICHTFSAP | YASLASELFQ | REVSVVDLVS |

300:

YASVWLFRGD | FVMDYPRPIM | PNMVFIGGIN | CANGKPLSQE | FEAYINASGE |

350:

HGIVVFSLGS | MVSEIPEKKA | MAIADALGKI | PQTVLWRYTG | TRPSNLANNT |

400:

ILVKWLPQND | LLGHPMTRAF | ITHAGSHGVY | ESICNGVPMV | MMPLFGDQMD |

450:

NAKRMETKGA | GVTLNVLEMT | SEDLENALKA | VINDKSYKEN | IMRLSSLHKD |

500:

RPVEPLDLAV | FWVEFVMRHK | GAPHLRPAAH | DLTWYQYHSL | DVIGFLLAVV |

534:

LTVAFITFKC | CAYGYRKCLG | KKGRVKKAHK | SKTH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

STRING:

9606.ENSP00000362508

MIM:

KEGG:

SMR:

Pfam:

String:

Uniprot:

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ELISA Kit for Human UDPGT 1-4

Cat.:

E12956h

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human UDPGT 1-4

Cat.:

U12956h

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96T

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Polyclonal Antibody for Human UDPGT 1-4

Cat.:

P12956Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human UDPGT 1-4

Protein for Human UDPGT 1-4

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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Linearity

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References

1.

"Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells."
Ritter J.K. , Crawford J.M. , Owens I.S.
J. Biol. Chem.266:1043-1047(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue: Liver.
2.

"A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini."
Ritter J.K. , Chen F. , Sheen Y.Y. , Tran H.M. , Kimura S. , Yeatman M.T. , Owens I.S.
J. Biol. Chem.267:3257-3261(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
3.

"Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus."
Gong Q.H. , Cho J.W. , Huang T. , Potter C. , Gholami N. , Basu N.K. , Kubota S. , Carvalho S. , Pennington M.W. , Owens I.S. , Popescu N.C.
Pharmacogenetics11:357-368(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
Zhang T. , Haws P. , Wu Q.
Genome Res.14:79-89(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-48
tissue: Liver.
6.

Guillemette C. , Levesque E. , Girard H. , Bernard O.
Submitted (2006-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
7.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
10.

"Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity."
Girard H. , Levesque E. , Bellemare J. , Journault K. , Caillier B. , Guillemette C.
Pharmacogenet. Genomics17:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
11.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142 AND ASN-348
tissue: Liver.
12.

"Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro."
Bellemare J. , Rouleau M. , Girard H. , Harvey M. , Guillemette C.
Drug Metab. Dispos.38:1785-1789(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
13.

"Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I."
Bosma P.J. , Chowdhury J.R. , Huang T.-J. , Lahiri P. , Elferink R.P.J.O. , van Es H.H.G. , Lederstein M. , Whitington P.F. , Jansen P.L.M. , Chowdhury N.R.
FASEB J.6:2859-2863(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CN1 PHE-376
14.

"Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II."
Aono S. , Yamada Y. , Keino H. , Hanada N. , Nakagawa T. , Sasaoka Y. , Yazawa T. , Sato H. , Koiwai O.
Biochem. Biophys. Res. Commun.197:1239-1244(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CN2 PRO-132 AND ASP-487
15.

"Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2."
Moghrabi N. , Clarke D.J. , Boxer M. , Burchell B.
Genomics18:171-173(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CN2 ARG-332
16.

"Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population."
Menard V. , Girard H. , Harvey M. , Perusse L. , Guillemette C.
Hum. Mutat.30:677-687(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-24 AND VAL-48

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